Research Articles
Beyond Genetics: Decoding the Epigenetic Blueprint of Sperm Motility and Morphology
This article provides a comprehensive analysis of the epigenetic mechanisms governing sperm motility and morphology, crucial determinants of male fertility.
DNA Methylation in Spermatogenesis: Mechanisms, Dysfunction, and Clinical Implications for Male Infertility
This article provides a comprehensive review of the pivotal role DNA methylation plays in orchestrating normal spermatogenesis and its direct association with male infertility.
Robust Quality Control Pipelines for Multi-Center Endometriosis GWAS: Ensuring Data Integrity from Genotyping to Discovery
This article provides a comprehensive framework for implementing robust quality control (QC) pipelines in multi-center genome-wide association studies (GWAS) of endometriosis.
Unraveling Familial Endometriosis: The Critical Role of Rare Genetic Variants in Disease Aggregation and Pathogenesis
This article synthesizes current research on the role of rare genetic variants in familial endometriosis aggregation, a area complementing common variant studies from GWAS.
Addressing Inter-Patient Variability in Microbiome Study Designs: From Foundational Concepts to Clinical Translation
Inter-patient variability remains a central challenge in translating microbiome research into reliable diagnostics and therapeutics.
The Oncobiome Revolution: Developing Microbiome-Based Diagnostics for Gynecological Cancers
This article synthesizes current research and future directions for microbiome-based diagnostics in gynecological cancers.
A Researcher's Guide to Contamination Control in Low-Biomass Endometrial Microbiome Studies
Accurate characterization of the low-biomass endometrial microbiome is critically important for understanding its role in reproductive health, IVF outcomes, and gynecological pathologies.
Validating Methylation-Driven Gene Expression: From Foundational Concepts to Clinical Translation in Independent Cohorts
This article provides a comprehensive roadmap for researchers and drug development professionals navigating the critical process of validating DNA methylation-driven gene expression changes.
Defining Differentially Methylated Regions (DMRs): A Comprehensive Guide from Detection to Clinical Translation in Complex Traits
This article provides a comprehensive resource for researchers and drug development professionals on defining and analyzing Differentially Methylated Regions (DMRs) in the context of complex traits.
WGBS vs. EPIC Array vs. EM-seq: A 2025 Researcher's Guide to DNA Methylation Analysis
Accurate DNA methylation quantification is pivotal for epigenetics research and clinical biomarker development.